eGlycemic Management Solution Safely Achieves Prescribed Glycemic Target with a Low Incidence of Hypoglycemia in Patients with Acute Myocardial Infarction in the Hospital

eGlycemic Management Solution Safely Achieves Prescribed Glycemic Target with a Low Incidence of Hypoglycemia in Patients with Acute Myocardial Infarction in the Hospital

Presentation

American Association of Clinical Endocrinologists (AACE) Annual Scientific & Clinical Congress

Date

May 2015

Authors

Melanie Mabrey,1,2 Jagdeesh Ullal,3 Raymie McFarland,1 Robby Booth,1 Amy Henderson,1 Joseph Aloi4

Objective

Acute myocardial infarction (AMI) patients presenting with hyperglycemia on admission have a higher mortality risk regardless of prior history of diabetes. A more specific marker for this increased risk is persistent and unresolved hyperglycemia. Proper screening for, and resolution of hyperglycemia in patients with AMI has been shown to have an impact on mortality. Many hospitals are challenged with implementing a comprehensive and standardized approach for identification of hyperglycemia and subsequent glycemic management. This study attempted to determine if Glucommander, a computerized intravenous and subcutaneous insulin-dosing algorithm can identify patients in need of intervention and be an effective method of improving glycemic management in patients with AMI. Most importantly, if it is possible to improve hyperglycemia without a subsequent increase in hypoglycemia.

Methods

222 patients identified with GlucoSurveillance as having two blood glucoses (BG) >180 mg/dL within 24-hour period were randomized to an intravenous (IV) insulin dosing regimen, and then transitioned to subcutaneous insulin therapy.

  • Arm1 = Glucommander IV and SubQ
  • Arm2 = Standard paper order sets.
  • Glucose target = 120-180 mg/dL.
  • Measured outcomes:
    1. General demographics.
    2. Average glucose reduction.
    3. Percent of glucose readings in target.
    4. Hypoglycemia: mild (<70 mg/dL) and severe (<40 mg/dL).
    5. Average glucose on day of discharge.

Results

Arm1 – 109 patients, average age of 64 years, A1c of 8.4 and an initial BG of 273.7 mg/dL. The average BG reduction was 132.3 mg/dL with 87.4% of glucose readings within target range. Hypoglycemia <70 mg/dL was 0.46% and <40 mg/dL was 0.04% and average glucose day of discharge was 141.4 mg/dL.

Arm2 – 113 patients, average age of 66 years, an A1c of 8.8 and an initial BG of 262.8 mg/dL. The average BG reduction was 60.9 mg/dL with 46.7% of glucose readings within target range. Hypoglycemia <70 mg/dL was 2.29% and <40 mg/dL was 0.06% and average glucose day of discharge was 201.9 mg/dL.


Arm 1
Glucommander
Arm 2
Standard Sets
Patients w/AMI 109 113
Average Age 64 66
A1c 8.4 8.8
Initial BG 274 263

Conclusion

Our results suggest using eGlycemic Management Solution (eGMS) with GlucoSurveillance to identify patients with hyperglycemia and AMI, then initiate and manage insulin with Glucommander in the hospital improves BG control. Patients achieve glucose target range at a higher percentage than standard paper order sets with less hypoglycemia. Additionally, patients were more likely to be discharged with blood glucoses in target. Further study is needed to assess implications for possible reduction in readmission and recurrent AMI as seen in DGAMI.

Affiliations

  1. Glytec, Waltham, Massachusetts.
  2. Duke University School of Nursing, Durham, North Carolina.
  3. Eastern Virginia Medical School, Norfolk, Virginia.
  4. Wake Forest Baptist Medical Center, Winston Salem, North Carolina.
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